Variation and association of fibronectin-binding protein genesfnbAandfnbBinStaphylococcus aureusJapanese isolates
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چکیده
منابع مشابه
Biochemical characterization of PE_PGRS61 family protein of Mycobacterium tuberculosis H37Rv reveals the binding ability to fibronectin
Objective(s): The periodic binding of protein expressed by Mycobacterium tuberculosis H37Rv with the host cell receptor molecules i.e. fibronectin (Fn) is gaining significance because of its adhesive properties. The genome sequencing of M. tuberculosis H37Rv revealed that the proline-glutamic (PE) proteins contain polymorphic GC-rich repetitive sequences (PGRS) which have clinical importance i...
متن کاملConstruction of a New Fusion Protein Vector Associated to Fibronectin Binding Protein A and Clumping Factor A Derived from Staphylococcus aureus NCTC8325
Objective(s) Staphylococcus aureus is a leading cause of many nosocomial and community acquired infections. According to many reports, antibiotic therapy can not guarantee the eradication of S. aureus infections. Thus designing an adhesin based vaccine could restrain the S. aureus infections. This study designed for construction of a new fusion protein vaccine against S. aureus infections base...
متن کاملAmino acid polymorphisms in the fibronectin-binding repeats of fibronectin-binding protein A affect bond strength and fibronectin conformation.
The Staphylococcus aureus cell surface contains cell wall-anchored proteins such as fibronectin-binding protein A (FnBPA) that bind to host ligands (e.g. fibronectin; Fn) present in the extracellular matrix of tissue or coatings on cardiac implants. Recent clinical studies have found a correlation between cardiovascular infections caused by S. aureus and nonsynonymous SNPs in FnBPA. Atomic forc...
متن کاملSFS, a novel fibronectin-binding protein from Streptococcus equi, inhibits the binding between fibronectin and collagen.
The obligate parasitic bacterium Streptococcus equi subsp. equi is the causative agent of strangles, a serious disease of the upper respiratory tract in horses. In this study we have, using shotgun phage display, cloned from S. equi subsp. equi and characterized a gene, called sfs, encoding a protein termed SFS, representing a new type of fibronectin (Fn)-binding protein. The sfs gene was found...
متن کاملbiochemical characterization of pe_pgrs61 family protein of mycobacterium tuberculosis h37rv reveals the binding ability to fibronectin
objective(s): the periodic binding of protein expressed by mycobacterium tuberculosis h37rv with the host cell receptor molecules i.e. fibronectin (fn) is gaining significance because of its adhesive properties. the genome sequencing of m. tuberculosis h37rv revealed that the proline-glutamic (pe) proteins contain polymorphic gc-rich repetitive sequences (pgrs) which have clinical importance i...
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ژورنال
عنوان ژورنال: Microbiology and Immunology
سال: 2016
ISSN: 0385-5600
DOI: 10.1111/1348-0421.12377